The Effect Of Experimental Abdominal Aortic Aneurysm In The Mice By Treatment With Tamoxifen

ObjectiveSelective estrogen receptor modulators ( SERMs ) , similar to estrogens, possess vasoprotective effects by reducing release of reactive oxygen species. Little is known about the potential effects of SERMs on the pathogenesis of abdominal aortic aneurysms (AAAs). This study's objective was to investigate the growth of experimental AAAs in the setting of the SERM tamoxifen.MethodsAAA model was established by perfusion of pancreas elasticity proteinase in 40 mices , which were divided into control 7d team , control 14d team , Tarn 7d team and Tarn 14d team. Tarn teams were treated by tamoxifen , 15mg/kg/d , to last a week. Seven days later , all animals underwent pancreatic elastase perfusion of the abdominal aorta. Aortic diameters were determined at that time, and aortas were harvested 7 and 14 days after elastase perfusion for haematoxylin - e-osin stain , verhorff stain and immunohistochemistry.ResultInfiltration of inflammatory cell and destruction of elastic fibers were evidently restrained. MMP -2 activity was 2.0 - fold higher (p <0. 01) on day 7 in the aortas of the controls compared to the tamoxifen - treated group's aortas. MMP - 9 activity was 1.9- fold higher (p < 0.01) on day 7 in the aortas of the controls compared to the tamoxifen - treated group's aortas. Macrophage activitywas 1.6-fold higher (p<0.01) on day 7 in the aortas of the controls compared to the tamoxifen - treated group's aortas. The treatment by tamoxifen inhibited AAA formation by 95 -99% .DiscussionThe selective estrogen receptor modulator tamoxifen inhibits the development of AAAs in male rats in association with an up - regulation of catalase and inhibition of aortic wall neutrophil infiltration.ConclusionTamoxifen inhibits the development of AAAs in male in association with inhibition of the expression of MMPs and the infiltration of inflammatory cell in aortic wall.