Experimental Study Of Effects And Mecha-nisms Of Fufangbiejiaruanganfang Drug Serum On Proliferation And Activation Of Rat Hepatic Stellate Cell Cultured With SEC Conditioned Medium

Hepatic fibrosis is a sure stage of development of all kinds of chronic hepatopathy to cirrhosis of liver. Pathologically, it is characteristic of proliferation and deposit of fiber tissue which is mainly collagenâ… andâ…¢in portal canal area and liver lobule. Up to now the mechanisms of liver fibrosis are not so clearly. And it is popularly thought that by virtue of the participation of several kinds of cell and cytokines extracellular matrix deposits excessively. It is well known that damaging factors bring about liver injury, then cause cellular necrosis of liver and inflammation. Cells, which are correlated with hepatic fibrosis secrete cytokines to activate HSC to develop mass of ECM. Subsequently the synthesis of ECM in liver is more than degradation of it, which leads to the occurrence of liver fibrosis. And a lot of study data indicate that the activation of hepatic stellate cell is central tache in the occurrence and development of liver fibrosis. Also, some studies indicate that both hepatic sinusoidal endothelial cells and HSCs are responsible for occurrence and development of fibrosis. SECs have several impacts on HSC by paracrine, which redound to the activation.And this makes HSC proliferate and transform into myofibroblast. Myofibroblasts have the function of secreting collagenâ… and contractibility. Then impel the occurrence of fibrosis and maintain the development of it. Today we realize that SEC's many functions as following:...