Study Of The Correlation Between HBsAg, HCV Expression In HCC And Pericarcinomatous Tissues And Clinic, Histology With Immunohistochemistry

Objective To study the correlation between HBsAg, HCV in HCC, pericarcinomatous tissues and clinic, histology.Methods The patterns of HBsAg and HCV in 100 cases of hepatocellular carcinoma(HCC) and their surrounding liver tissues were studied on paraffin-embeded sections with immunohistochemistry technique, pericarcinomatous tissues were staged;AFP, Hyaluronic acid (HA), procollagen III(PIIIP), type IV collagen(CIV), laminin(LN) were detected by radioimmunoassay;the activities of T- lymphocyte subset and NK cell were examined;the correlation were studied.Results The levels of AFP, HA, PIIIP, C-IV, LN in HBV and HCV coinfection is the highest in the four groups. The levels of AFP, HA, PIIIP, C-IV, LN in the group which is not infected by HBV, HCV is the lowest in the four groups. HBV, HCV expression were positively correlated with AFP, HA, LN and C-IV. The immunologic derangement in HCC were concerned with HBV, HCV infection.Conclusions The background of HBV, HCV virus infection had a direct influence on the levels of AFP, HA, PIIIP, C-IV, LN, the fibrotic staging. On the one hand, virus infection is one of the reasons which cause the liver cancer;on the other hand, perennial virusemia will aggravate pathological changes of liver tissue. The antivirus intervening treatment of hepatitis is significant for the prognosis of liver cancer.