Expression Of Adrenomedullin And Relationship Of Microvessel Density With Adrenomedullin In Granulosa Cell Tumor Of Ovary

Granulosa cell tumors are serious ovarian neoplasms that can occur in women of all ages. While there have been numerous attempts to under -stand the cause of these malignancies, the pathogenesis of granulosa cell tumors still re- mains largely unknown. So it is necessary to search for relative factors in order to diagnose and treat the disease when it is in early stage and give effective therapeutic methods.Adrenomedullin (ADM) is a novel vascular endocritic hormone.Which was discovered by Japanese scholar Kitamura in 1993. It has stronger function of vascular dilatation and depressurization, ADM is a pluripotent hormone with structural similarities to calcitonin gene related peptide (CGRP), which is expressed by many tissues in the body and shows a remarkable range of effects mediate by paracrine/autocrine and possibly endocrine mechanisms. ADM has been implicated as a mediator of several pathologies such as cardiovascular and renal disorders, sepsis, inflammation, diabetes and cancer, among others. which is found in a variety of tumor cell lines or malignant tissues and can enh ance the growth of tumor cells by several ways.â‘ It has the proliferative capabilities in a wide variety of cancer cells. Many studies show ADM stimulates growth in several cancer types. ADM has been shown to induce cAMP production in tumor cells, so it may function as a growth regulator in tumor proliferation. The neutralizing monoclonal antibody to ADM inhibited tumor cell growth in a dose-dependent manner, suggesting that ADM is a novel mitogenic regulatory peptide.â‘¡ADM is an apoptosis...