DoxazosinMesylate With The Physical Therapy In The Treatment Of Chronic Prostatitis/chronic Pelvic Pain Syndrome

Objective: To evaluate the efficacy of DoxazosinMesylatematching the physical therapy in the treatment ofchronic prostatitis/chronic pelvic pain syndrome.Method: Sixty cases of patients who had been diagnosed ofchronic prostatitis/chronic pelvic pain syndrome. Theefficacy was evaluated by NIH Chronic ProstatitisSymptom index after a three-month follow up.High level α1-adrenopceptor distributes in theprostate's substantia and amicul the proximal urethraand the base of bladder distribute.High levelβ-adrenopceptor distribute in the bladder.Sphineter ofurethra is controlled by α1-adrenopceptor.Barbalias et.discovered that because the patients with prostatitishyperreactivity of adrenergic nerve cause the highforce of urethra and prostatic part,accordinglyinducing high pressure of paralyse urine back flowingthe prostate, evoking the prostatitis.DoxazosinMesylate is the selectivity antagon ofα1-adrenopceptor which can inhibit the tension of themuscle of prostate and urinary tract despress the flowresistance of urine.DoxazosinMesylate have high affinity withα1-adrenoceptor,generate the close-dependentlaxiatas of prostate to improve the LUCT ofpatients.Perineal position cavitas pelvis pain afterejaculation and odynuria are possiblely result inmusclestone higher which induced by flammation ofhydropsia,the substance and glandular of prostateand congestion of prostate muscle spasm of bladderneck,prosterior urethra.Above-mentioned symptomscan be improved by α1-adrenoceptor loosed thesmooth muscle.The chronic prostatitis must fully attent the regularityof daily life. They must avoid tiredness, long timesitting,drinking, smoking.Usually hip bath in thewarm water,one hour walking every day and et. canrelieve the symptoms. Physical treatment haveimportant effect in myalgia of cavitas pelvis.Standardized monotherapy has poorly effective intreatment of chronic prostatitis. Multi-treatment andcontinuous course treatment have big help to relievethe symptomatic.Results: After the three-month follow up,the totalimprovement rate is 91.7%.The pain and voidingscore of the symptom index were lowered from7.98±1.69 to 4.88±0.87 show great statistic differences(P < 0.01) and 2.72±1.04 to 1.20±0.68 showstatistic differences( P<0.05);Quality of life score thesymptom index were lowered from 7.60±1.11 to4.30±0.72;The symptom index score changed from18.28±2.08 to 10.42±1.18 .Show great statisticdifferences (P< 0.01)。Conclusion: The DoxazosinMesylate matching the physicaltherapy in the short-term treatment of chronicprostatitis/chronic pelvic pain syndrome is effective.