Feasibility Of Acute Hypervolemic Hemodilution Using The Double Variable Parameter Formula

Objective: To investigate the effect of acute hypervolemic hemodilu-tion (AHHD) on the patients and clinical security and feasibility by using the double variable parameters formula. Methods: Thirty two patients, ASA I — II, aged 20-60, weighted 45-70kg, scheduled for otolaryngocal surgery, were divided into two groups randomly: The AHHD group (n=16) and the control group (n=16). AHHD was performed using the double variable parameters formula (the perfusion volume = [ (H₀-H_f) /Hf]× weight(kg) × 7% ×1000) after general anesthesia. Arterial and venous blood samples were taken for determination of Hct, Hb, liver function, kidney function, coagulation function, PaO₂, SaO₂, PvO₂, SvO₂, BE and lactic acid before and after AHHD, during and at the end of the operation. CaO₂, C vO₂, ERO₂ were calculated by special formula. Results: Compared with basic data, after AHHD Hb and Hct dropped by 34.5% and 32.6%, and reached to the target Hb (90g/l), Hct (26%) respectively. CaO₂ and CvO₂ also dropped by 20.7% and 20.5% respectively, which were still several times higher than normal levels and the difference of which were statistically significant. Compared with the control group, ERO₂, SvO₂, Lactic acid, T, BE and pH of the AHHD group dropped slightly and without statistical difference. Conclusions: After moderate AHHD, the cardiac and pulmonary functions remain stable state, the changes of MAP and CVP are remained within the normal range, and the Lactic acid and ERO₂ are not significantly affected. Therefore, According to the double variable parameters formula were performed AHHD which is feasibility and security in clinical practice.