Study On The Relationship Between Serum Hepatitis B Virus DNA Load In HBsAg Positive Pregnant Women And IFN-γ, IL-4, IL-6 To Intrauterine Infection Of Hepatitis B Virus

Objective: To Study on the relationship between Serum Hepatitis B Virus DNA Load in HBsAg Positive pregnant women and IFN-γ, IL-4, IL-6 to intrauterine infection of hepatitis B virus. Discussing the mechanism of intrauterine infection of hepatitis B virus can provide the theory for the enhancement of the cell immunity function of the pregnant woman and for the decrease of intrauterine infection of hepatitis B virus.Methods: The pregnant women were divided into two groups: 80 cases with positive HBsAg were included in the study group, the control group included 20 cases of normal pregnant women. By using diantibody sandwich enzyme linked immuneadsorb assay (DAS-ELISA), the serum HBVM, HBVDNA, IFN-γ, IL-4 and IL-6 levels in maternal and neonates were determined respectively.Results: In the study group, the incidence of HBV intrauterine infection was 13.75%(11/80). The IFN-γlevels of the pregnant women with intrauterine infection were significantly lower than those without intrauterine infection and control group (P<0.01), IL-4, IL-6 levels was contrary to IFN–γ(P<0.01).There had no significant difference of IFN-γ, IL-4, IL-6 levels between women without...