Effect Of HES130/0.4 On S100B Levels And Cerebral Oxygen Metabolism In Open Cardiac Surgery Under CPB Without Cardioplegia

Objective To observe the effect of HES130/0.4(Voluven﹫)as priming solution on S100B levels and cerebral metabolism of oxygen in open cardiac surgery under cardiopulmonary (CPB) without cardioplegia. To evaluate the protective role on cerebral injury of HES130/0.4 as priming solution on cerebral injury during CPB and open cardiac surgery. Methods Forty ASAⅡ～Ⅲpatients scheduled for elective surgical repair of atrioseptal defect (ASD) or ventricular septal defect (VSD) , mitral valve replacement(MVR) under CPB with moderate hypothermia were randomly divided into two groups of twenty each, namely voluven group and Succinylated Gelatin (or gelofusine) group. Premedication consisted of intramuscular pathidine 1mg·kg-1 and scopolamine 6μg·kg-1.There are no obvious difference in the methods of anesthesia and CPB between two groups. When CPB began moderate hypothermia was carried and while the primary operation procedures were completed rewarming began. ECG, HR, BP, MAP, CVP, SpO2, PetCO2 and body temperature (naso-pharyngeal and rectal) were continuously monitored during operation. Blood samples were obtained from jugular vein and radial artery for blood gas analysis and blood glucose immediately before CPB(T0), 20 minute after CPB (T1), immediately after termination of CPB (T2), one hour after termination of CPB (T3), 24 hours after termination of CPB (T4), based on which CMRO2/CMRGLU was calculated out .The central vein blood samples were collected on above-mentioned time points for determination of blood concentrations of S100B protein. The serum S100B protein levels were measured by ELISA. Result The demographic data,...