The Value Of Urinary Albumin Concentration In Epidemiologic Survey And Relationship Between The Prevalence Of Microalbuminuria And Metabolic Syndrome

Objective 1. To study the dependability between urinary albumin (ALB) concentration of spot urine collection and urinary albumin to creatinine ratio (ACR) in the diagnosis of microalbuminuria and cut-off value of urinary albumin concentration. 2. Observe the prevalence of microalbuminuria (MAU) in Guangxi province. 3. Analyze the relationship between the prevalence of microalbuminuria and components of metabolic syndrome in Guangxi.Methods A total of 3018 Guangxi Chinese (men 1648, women 1370) aged over 10 years were included. Body mass index (BMI), blood pressure, waist circumference, fasting plasma glucose, lipid profile and plasma insulin concentrations were measured in all subjects. Oral glucose tolerance test was performed in those subjects without knowing the diabetic history. Urinary albumin was measured in spot urine samples of early morning (8am to 10am) in all cases. Of 3018, 704 cases'creatinine was tested and then ACR was calculated. Microalbuminuria was diagnosed when albumin was between 30 and 300mg/L.Results (1) The diagnosis of microalbuminuria with ALB was near to it with ACR. When ALB exceeded 29.08mg/L (sensitivity 93.42% , specificity93.31% , Youden index 0.867 ) , the crude accuracy was 93.2%(Kappa index 0.71 , P<0.001). (2) The median level (inter-quartile) of urinary albumin in 3018 Chinese of Guangxi was 7.18(12.2)mg/L, 7.21(12.07)mg/L in male and 7.14(12.42)mg/L in female, and there was no significant difference (P>0.05). (3) Urinary albumin levels in the subjects of 60~ and 70~years old were higher than the groups of less than 40~years old in male(P<0.05), and was higher in the subjects of 70~ than in the group of 30~ in...