The Alteration Of Na～+-K～+-ATPase Activity And The Reaction Of Dexamethasone Observed On Different Acute Lung Injure Models Of Rats

Object: Acute lung injury (ALI), a syndrome of pulmonary inflammation characterized by alveolar-capillary increased permeability, is a serious complication of patients with critical illnesses, results from a variety of clinical reasons such as sepsis, shock and trauma and even leads to acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS). The ALI induced by endotoxemia (factor outside lung) and acid inhalation (factor in lung) characterized by noncardiogenic pulmonary edema is very common. The Na~+-K~+-ATPase plays an essential role in active alveolar epithelial fluid resorption. Glucocorticoid (such as dexamethasone) can increase the Na~+-K~+-ATPase hydrolytic activity and expression level. The purpose of the study was to investigate the role of the Na~+-K~+-ATPase in the resolution of pulmonary edema in lung epithelial cells of rats with ALI induced by hydrochloric acid (HCl) and lipopolysaccharide (LPS) and the therapeutic value of dexamethasone. Materials and Methods:1 The animal groups and models Ninty-six male pathogen-free...