Case-control Study On Relationship Of PPARγ C161â†'T And PPARδ+294T/C Single Nucleotide Polymorphisms And Hypertension In Chinese Han Population

Objective: There are many factors that can cause primary hypertension, and as the same time, the inherent factor and the environment factor are the two main factors, they interact each other and lead to primary hypertension. Peroxisome proliferator activated receptors (PPARs) are ligand activated transcription factors. Three distinct PPARs, termed alpha (PPARA), gamma (PPARG), and delta (PPARD), have been isolated. They are encoded by separate genes and characterized by distinct tissue and developmental distribution patterns. PPARs involved in the regulation of lipid metabolism, glucose metabolism, inflammatory reaction, immune reaction, adipocyte differentiation,growth and apoptosis, endothelial function, and so on. So many common diseases, such as cardiovasular disease, obesity, diabete mellitus, tummor and inflammation, are associated with PPARs. Therefore, to investigate the relationship between PPAR and primary hypertension by genetic level is very important. It can help to judge the susceptible person of primary hypertension, and treat the disease through genetic method. There are 137 hypertension subjects and 125 healthy...