Alteration Of The Activity Of Peroxisomal Fatty Acidβ-oxidation In The Livers Of Insulin Resistant Rats Resulted In By High Sucrose, High Saturated Fatty Acid And High Unsaturated Fatty Acid Diets.

Objective: The morbidity of diabetes mellitus (DM) and impaired glucose tolerance (IGT) is increasing with the effect of modern life style of high calorie and low activity. Generally speaking, plasma free fatty acids are inceased in DM and IGT patients. Our previous study indicated that the serum free fatty acids increased in these patients were mainly some very-long-chain fatty acids, including C22:0 and C24:0, and arachidoniac acid. It has been testified that along with the serum increased FFA, the function of peroxisomes are altered in type 1and type T2 DM animals, and that the activities of catalase , acyl-CoA oxidase and peroxisomal fatty acidβ-oxidation are increased. Our previous study demonstrated that high fat diet resulted in insulin resistance (IR) and high serum FFA in rats. In this study, we used the different foods, high sucrose diet, high saturated fatty acid diet and high unsaturated fatty acid diet to feed the adult Wistar rats in order to manifest effects on the activities of some enzymes involved in peroxisomal fatty acidβ-oxidation in rats, and further investigate possible factors or chanisms related with them.