Study Of Target Organs Toxicity Induced By Organic Extract From JiaLing River In Chongqing City

Since 1950's, organic pollution has become more and more serious following the process of global industrialization and the abuse of chemicals. Most of the organics were part of persistent organic pollutants (POPs), which were harmful to human health and ecological system. It reminds us the situation is very serious that main rivers in China have been polluted by organics on different levels. The Three Gorges Project is a great work to take advantage of the water resources. But it will certainly affect the ecological environment when it was built up. Jialing River locates in the reservoir region and is the main water supply of Chongqing City. If we could know the features and toxicity of pollutants in the river clearly, we will offer scientific evidences in evaluating the safety of the water and protecting people in Chongqing and cities along the down-stream of the Yangtze River.With the organic pollution becoming worse in recent years, both governments and the public have paid great attention to it. Many labs all around the world have begun their researches to detect the toxicity of organic pollutants. Some researchers cared about toxicity of single compound. Others interested in approaching the harm of mixtures extracted from river water. Many zoic, cellular and molecular techniques were used to verify the features of different organic extract. However, few researchers have tried to do some work on systematic observation of animals in chronic or subchronic toxicity test. But only chronic taking with suitable doses can imitate the actual mode of people drinking water and provide believable data to direct our measures in environmental protecting.In our study, organic extract from Jialing River was collected by method of solid phase extraction. A subchronic toxicity test for rats was adopted to investigate the main toxic target organs. At 2L, 12L, 72L/(kg.bw) doses of pouring into stomachs every two days, pathological changes, hematological parameters, analysis of urine, serum biochemical parameters and indexs related to free radical damages were observed. Based on these results, we expanded our research to more details. The genetic, reproductive, neural and immune...