The Pharmaceutical Study And Preparation Of Rifampicin Suppository

Purpose:With broad spectrum antiseptic effect, the Rifampicin has been the first priority for anti-tuberculous, which has been widely used many years. However, due to large dosage and greater side effect of oral administration, especially its higher toxicity to the liver, its use is restricted. Hence, we prepared Rifampicin suppositories by ourselves with the theory that most of the rectal administration drug will not go through the liver but enter the blood cycle directly, and determined the bioavailability of RFP in rabbits after oral and rectal administration respectively. Accordingly to ascertain whether it is possible or not to abate Rifampicin's toxic and side effects to the liver by changing the administration way, without causing any impact on its therapeutical effect.Methods:1. To determine the equilibrium solubility of Rifampicin in different dissolvent, apparent oil/water distribution coefficient in various supplementary materials by ultraviolet spectrum.2. Based upon the preformulation research results, various Rifampicin suppositories were prepared by melt time method, with glycerogenlatin, water-soluble base, fatty base, O/W emulsion type base.3. The Rifampicin content in the suppository was determined at 474nm by ultraviolet-visible spectrum. To determination Rifampicine's dissolution in suppositories was rotating basket method and then we made comparison the dissolution to the Rifampicin capsule.