| Objective: Bronchiolitis is a common disease in infant. Clinically, bronchiolitis is characterized by a harsh paroxysmal cough and lower respiratory-tract signs such as wheezes and crackles. About 50-70% of infants who have acute bronchiolitis have subsequent episodes of audible wheezing which are almost certainly asthma, acutely hurt the physical and mental health of the children. However, the mechanisms of it remain unclear. Cysteinyl leukotrienes(CysLTs) constitute a class a potent biological inflammatory mediators derived from arachidonic acid(AA) through the 5-lipoxygenase (5-LO) pathway, which are composed of leukotriene C4(LTC4),leukotriene D4(LTD4) and leukotriene E4(LTE4). CysLTs have many biological effect: cause smooth muscle constriction and proliferation, secretion of mucus, promote eosinophil recruitment and activation, increase microvascular permeability , promote the airway remodeling. These reasons altoghter cause the airway hyperresponsivenes, then the above clinical symptoms can be seen. Nowadays, the role of CysLTs in asthma has been affirmation, the clinical,pathological and immunologic similarities between bronchiolitis and asthma have led to the speculation that the two disease states have similar pathophysiologic mechanisms. Total CysLTs production is quantified by measurement of LTE4 in a spot urine sample. Because of this, the study is designed to test the urinary levels of LTE4 in infant with bronchiolitis, the objective is to investigate the effect of CysLTs on the pathogenesis of bronchiolitis, analyse the correlation between the bronchiolitis and asthma.Mothods: We studied 32 subjects (18 acute phase, 14 Recovery... |
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