Intravenous Transplantation Of Mesenchymal Stem Cells In Treating Infarcted Myocardium

It is traditionally believed that myocardial cells cannot be regenerated, and once they are destroyed, they can not be repaired. The dead myocardial cells will be replaced by fibroblasts, which results in the changes of cardiac structure, heart failure and even death. A novel therapeutic option to prevent the progression toward heart failure involves the introduction of stem cells into the infarct area. This transplantation of MSCs may repair damaged myocardium, thus preventing the thinning of the ventricular wall, the scar formation and the decline of heart function. Mesenchymal stem cells (MSCs) possess pluripotential capabilities and MSCs' capabilities of myogenic differentiation in small animals also have been proved in some experiments. It is even known that MSCs have been used for clinic.However, following myocardial infarct, myocardium will experience inflammation and fibrosis. These pathological changes will affect the...