Effects Of Exogenous Axin Gene On The Biological Characteristics Of C6 Glioma Cells

Axin, the product of the mouse Fused (Fu) gene, was originally identified as an inhibitor of the Wnt signaling pathway, in that it regulates embryonic axis formation. Axin was initially identified as an axis inhibitor. It is also a very important tumor suppressor. As a scaffold protein, Axin has many binding domains, through which it interacts with many important components of signaling pathways, to regulate the balance of the signaling transduction together with other factors. Axin has emerged as a major scaffold protein for regulating a variety of signaling pathways and biological functions. To date, Axin has been implicated in at least four different signaling pathways: the Wnt, JNK, p53, and TGF-β signaling pathways. These signaling pathways regulate cell fate including cell growth, proliferation, differentiation, development and apoptosis. Axin positively regulates the JNK (apoptosis) signaling pathway and negatively regulates the Wnt (survival) signaling pathway. So this arose more people's interest to study the relationship between Axin and human tumor.Defected in different components of the Wnt signaling pathway promote tumorgenesis and tumor progression. Mutations of Axin have been detected in medlloblastoma, hepatocellular carcinomas, ovarian...