Experimental Study On Resveratrol Suppresseing Growth Of Human Glioma Cells And Tumor Angiogenesis In Nude Mice

Resveratrol is a naturally occurring polyphenolic compound highly enriched in grapes, peanuts, red wine, and a variety of food sources. Resveratrol have been studied for more than 30 years. Earlier studies of resveratrol focused on their activities against bacteria, inflammation, allergy, oxidation and free radicals. In recent years, resveratrol was further demonstrated to be an antitumor and chemopreventive agent and found to affect cellular proliferation through its action on tumor initiation, promotion, and progression. Resveratrol has been found to inhibit the proliferation of several kinds of tumors such as leukemia, prostate, breast, and colon cancers.The prognosis of patients with malignant glioma, the most common primary brain tumor, is quite poor. Even using multidisciplinary treatment strategies including surgery, radiotherapy, and chemotherapy, the life expectancy of patients with malignant glioma is usually <1 year from the time of diagnosis, and the 5-year survival rate is <5.5%. All though there were some medicines, but most of them were also harm to pataint's health. Therefore, developing a better therapeutic strategy for malignant brain tumors is mandatory. Resveratrol as a naturally occurring polyphenolic compound may be considered a possible treatment medicine for glioma.Although resveratrol can inhibit the growth and induce the apoptosis of many tumor cells, there is little report about gliomas. The mechanisms of the antitumor activity of resveratrol are not yet fully understood, although some mechanisms have been proposed. The induction of apoptosis and the suppression of angiogenesis might be two main mechanisms. However, the mechanisms of the resveratrol-induced apoptosis of cancer cells are also...