The Expression Of URG11 In Gastric Cancer And Its Roles In Stimulation Of The Growth Of Gastric Cancer Cells

[Background]Upregulated gene 11 (URG11), a unique gene upregulated by HBx, encodes a 68kD protein ,which presents Chordin-like cysteine-rich (CR) repeats (also referred to von Willebrand factor type C (VWC) modules)and a single C-type lectin domain .Chordin-like cysteine-rich (CR) repeats have been identified in 200 extracellular matrix proteins. These repeats, named on the basis of amino acid conservation of 10 cysteine residues, have been shown to bind to members of the transforming growth factor-β (TGF-β) superfamily and are proposed to regulate growth factor signaling.These domains have been observed in many other proteins and may participate in cell/cell recognition and cell/matrix interaction, both of which are important in cell fate decisions that distinguish normal cells from tumor cells . Moreover, C-type lectin domains have been found in some proteins...