Effect Of Stem Cells Derived From Umbilical Cord Blood Transplantation On Rotational Behavior And Content Of Striatal Dopamine In PD Rat Brain

The newly statistic datas revealed that the incidence of Parkinson's disease(PD) is 0.2% of population, 1.4% of population over the age of 55,2% in population over the age of 65,and 3.4% in population over the age of 75,so it is regarded abroad by each country.Although several hypotheses have been put forward,the underlying etiology of PD is still unknown.PD is characterized in the progressive death of dopaminegic neurons in the substantia nigra pars compact(SNc) and consequently the loss of dopamine(DA) in the striaturn.When the death of dopaminergic neurons exceeds 50% in the substantia nigra and the loss of DA in the striaturn is over 85% ,clinical symptoms such as static tremor,rigidity and dyskinesia may appear.For the pathogenesis is unclear,therapies have been focused on supplement of DA in the striatum .Lovodopa,a precursor of DA,and other dopamine agonists alleviate symptoms in PD patients but their effects decrease with the progress of the disease.Psychiatric symptoms would appear with such treatment for a long time .With the improvements of the stem cell's research, the therapy of cells supplement becomes a research point.Mesenchymal stem cells(MSCs) is the portion of adherent cells...