The Experimental Study Of Human Umbilical Cord Blood Mononuclear Cells Transplantation In Spinal Cord Injury

Spinal cord injury (SCI) is a common disease in clinic, and the serious spinal cord injury is easily happened to adult people, furthermore, these are rising in our country year after year. However, due to the limited neuronal survival, the lack of spontaneous axonal regeneration and the inhibitory glial environment, self-repair after damage of the mammalian central nervous system (CNS) is rather poor. In the past decade, basic science advances in spinal cord injury and regeneration research have led to a variety of novel experimental therapeutics designed to promote functionally effective axonal regrowth and sprouting. Therefore, external interventions such as cell transplantation and neurotrophic factors delivery overcoming the inhibitory environment at the injury site could stimulate some of the remaining intrinsic plasticity of neurons and, thus, to foster the healing of the otherwise nonregenerative CNS.Umbilical cord blood is ideal experimental material, because of abundant sourceseparating and purifying easy, moreover ABO and HLA antigens untreated on umbilical cord stem cells surface, so not to induce immunoreaction. Investigation showed that stem cells umbilical cord blood-derived could also differentiate into neurons, astroglias and oligodendrocytes. In our research, after mononuclear cells from human umbilical cord blood's migration and differentiation , Specific Antigen NSE of mature neurons and glial fibrillary acidic protein(GFAP) of astrocytes expression , regeneration...