| Liver transplantation (LTx) has become the preferred treatment for the end-stage liver diseases. However, although there are some improvements in surgical procedures, organ preservation and immunosupression protocol, primary non-function and early loss function are still the major problem influencing liver transplantation results. 5%~15% patients were obliged to make the second transplantation because of PNF leading to hepatic failure, hepatic function turbulence occurred in 10%~25% patients early after liver transplantation. Ischemic reperfusion injury is the important factor, it degrades the ability of metabolism deintoxication of liver and heightens the resistance of microcirculation, when severely, hepatic function failure will happen. So to alleviate the transplanted liver injury is emphasis to improve the quality of liver graft, to reduce PNF and to increase the success rate.Heme oxygenase (HO)-1 is a rate-limiting enzyme which catabolizes heme into carbon monoxide (CO), iron and bilirubin. HO-1 is its inducible type as well as heat shock protein 32(HSP32). HO-1 is proved to be a stress protein, many factors including heavy metal, heat shock, glutathion exhausting, ultraviolet radiation, endotoxin, ischemic-reperfusion, hypoxia and hyperxia can induce expression of...
|
PDF Full Text Request