Changes Of Keratinocyte And Hepatocyte Growth Factor Contents In The Bronchoalveolar Lavage Fluid And Serum Of The Patients With Acute Lung Injury

Since the discovery and characterization of the epithelial-specific growth factors keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF),their roles in lung inflammation and repair have been widely investigated. Over the past 10yr,it has become increasingly clear that HGF and KGF paly important roles in the injured lung and ultimately may have therapeutic potential in lung disease. Regardless of their therapeutic potentials, studies of the unique roles of these growth factors in the pathogenesis of acute lung injury may be helpful to understand the complex pathophysiology of inflammation and repair in the lung.Objectives: TO detect the levels of keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF) in the bronchiol alveolar lavage fluid (BALF) and serum of patients ith acute lung injury(ALI)and investigate the significance of the growth factors in the pathogenesis of ALI.Methods: Enzyme-linked immunoadsordent assay(ELISA) was used to detect the levels of HGF and KGF in the BALF and serum of patients with...