JAK2V617F Point Mutation In Hematological Malignancies

Chronic myeloproliferative disorders (CMPDs) are malignant clonal hematopoietic stem/progenitor cell disorders characterized by excessive proliferation of one or more myeloid lineages in the bone marrow. The proliferation results in increased numbers of granulocytes, red blood cells, and/or platelets, with relatively normal morphology and function. Splenomegaly and hepatomegaly are common symptoms.Traditionally, CMPDs are categorized into two types: the "classic" MPDs and "atypical" MPDs. Classic MPDs comprise four subtypes: chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and chronic idiopathic myelofibrosis (CIMF). Atypical MPDs (aMPDs) are rare and more nebulous, including chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), chronic neutrophilic leukemia (CNL), systemic mastocytosis (SM), chronic basophilic leukemia (CBL), hypereosinophilic syndrome/ chronic eosinophilic leukemia (HES/CEL), and unclassifiable cases (UMPDs).The molecular pathogenesis of CMPDs remains unclear, except for CML with Philadelphia-chromosome (Ph) and BCR/ABL fusion protein. Recent studies have suggested that protein tyrosine kinase (PTK)...