Dynamic Changes Of Early Skin And SdLN Immune Responses In C57BL/6 Mice Vaccinated With UV-attenuated Schistosoma Japonicum

Schistosomiasis is still a serious threat to public health throughout the world. Nowadays in China, endemic for schistosomiasis japonica, there are more than eight hundred thousand patients and near one hundred million people being threatened according to the countrywide investigation in 2003.During the last 20 years, it is the worldwide scientists' consensus that to develop an effective anti-schistosomiasis vaccine in order to prevent reinfection after chemotherapy. If it was successful, we would realize our object to control schistosomasis by combining short-acting chemotherapy with long-acting immune preventionFor a long time, the dominant strategy for vaccine development was to mimic protective immune responses in hosts after natural infection. However, even if the immune responses induced by infection had some resistance to reinfection, it was in low level and non-eliminating. Furthermore, it was impossible to avoid reinfection. Compared with it, attenuated cercariae (AC) were found to induce much higher level of protection in various animal models than any...