Study Of Molecular Epidemiology On Polymorphisms Of DNA Repair Genes And Susceptibility Of Lung Cancer In Chinese

Part â… A novel promoter polymorphism (T-77C) of DNA repair gene XRCC1 is associated with risk of lung cancerX-ray repair cross complementing group 1 (XRCC1), a scaffolding protein, is one of the most important proteins involves in DNA repair pathways and plays a key role in the repair of DNA SSBs (double strand breaks) and base damage induced by oxidants such as smoking. Associations between XRCC1 polymorphisms that cause amino acid substitutions (e.g. Arg194Trp and Arg399Gln) and susceptibility to cancer have been extensively investigated in many cancer sites. The different susceptibility to lung cancer may be induced by different repair capacity of XRCC1. In this study, we investigated the association between genetic variants of XRCC1 and the risk of lung cancer by PCR-restriction fragment length polymorphism (RFLP) assay.[Objective] To study the distribution of three polymorphisms of XRCC1 gene (T-77C, Arg194Trp and Arg399Gln) in lung cancer cases and cancer-free controls and to investigate the association between variant genotypes of XRCC1 gene and individual's susceptibility to lung cancer in Chinese.[Methods] In this case-control study including 710 patients with incident lung cancer and 710 cancer-free controls frequency matched on age, sex and residential area, we genotyped a novel T-to-C transition at...