Influence Of Human Systemic Lupus Erythematosus Serum On The Development Of Dendritic Cells Derived From Cord Blood CD34+ Hematopoietic Precursor Cells

Systemic lupus erthematosus (SLE) is a systemic autoimmune disease which affects multiple organs. Because SLE etiopathology is poorly understood, now, SLE therapy is just based on nonspecific immunosuppression and prednisone, but the side effect is great. Now, hematopoietic stem cell transplantation (HSCT) is increasingly being used for treatment of serious autoimmune diseases, but the patients accepted allogene HSCT had been of recurrence. Although we do not know whether the hematopoietic stem cell of the patient is abnormal, the phenomenon of recurrence after allogene HSCT implies us to investigate the influence of SLE serum upon the differentiation of hematopoietic stem cell.Blood stem cells (BSCs) are the most primitive cells in the immune system and can be differentiated into many kinds of cells. As the regulatory cells of immune response, dendritic cells (DCs) have been attracted more and more attention in the field of autoimmune diseases. From the research results of the past decade, DCs may take part in the outbreak of SLE. Therefore, we wonder whether some cytokines in the SLE sera environment may induce the abnormal DCs derived from blood...