Evidence-Based Medicine And Meta-Analysis Of Secondary Surgery In Recurrent Ovarian Cancer

Background: Epithelial ovarian cancer is recognized as a chronic disease with low diagnosis rate and high mortality. Despite significant improvement in the surgical care and the introduction of new and more efficacious chemotherapy combination, the majority of women diagnosed with advanced — stage cancer suffer from recurrence of their disease. Since therapy that can cure recurrent disease is essentially nonexistent, attempts at prolongation of overall disease—free survival become an alternative goal. Especially the effect of secondary cytoreductive surgery (SCR) is debatable.Objective: Use the systematic review and Meta—analysis to study the relative factors and to evaluate secondary surgery in the median survival time of recurrent epithelial ovarian cancer patients.Materials and Methods: A systematic review of clinical trials of secondary surgery of recurrent ovarian cancer was performed. Trials were identified by searching for Medline, Pubmed, Chinese Biological Medicine Database and Chinese EBM Database. The following outcomes were assessed: The number of patients accepting the secondary surgery and their median survival time. According to the different definitions of optimal SCR, the subgroups were designed as the macroscopic — free residual disease , the residual disease≤2cm , the residual disease≤1cm and the suboptimal SCR. Fisher's method was used to perform statistical...