Relationship Between Neural Remodeling And Inducible Ventricular Arrhythmias After Myocardial Infarction In Rabbits And Metoprolol Intervention Study

Background and objectsVentricular tachycardia (VT) and ventricular fibrillation( VF) are major causes of morbidity and mortality in healed myocardial infarction. Previous studies have focus on the mechanism and control of these malignant arrhythmias, especially in ventricular remodeling and electrical remodeling. Ventricular arrhythmias mainly occur in three phases which firstly centralize at 5 to 48 hours after MI, then at several days to weeks and reappear at several months or years after MI. Recent studies show MI results in neural remodeling which plays important roles in arrhythmogenesis, and responsible for sudden cardiac death. The concepts renewed the opinions of prevention and control of ventricular arrhythmia after MI.The main objects of this study are: 1) Immunohistochemistry and RT-PCR were used in a healed animal MI model to observe the character of neural remodeling. 2) To approach the relationship between neural remodeling and incidence of inducible ventricular arrhythmia. 3) To test the hypothesis that beta-adrenergic blocking agent metoprolol may improve neural remodeling and decrease ventricular arrhythmias vulnerability in healed MI.Methods...