| BackgroundsCoronary micro-embolization (CME) frequently happened in several clinical settings such as the spontaneous coronary plaque rupture, plaque rupture induced by mechanical intervention of PCI, incomplete thrombolysis during fibrinolytic therapy, etc. CME severely affects both the ventricular function and the clinical prognosis. Up to date, the most of studies, however, more address the acute detection and management of CME, and the chronic adverse effects of CME and its treatment remains unclear.ObjectivesThe aim of this study was to observe the impacts of simvastatin on the micro-vascular protection and angiogenesis in myocardium in a rat model with CME; to explore the possible mechanisms of simvastatin on micro-vascular protection and angiogenesis.MethodsWe created a rat model of CME by injecting a suspension of microthrombotic particles into left ventricle when clamping the ascending aorta. The microthrombotic particles were generated from the rat clots. Forty rats were randomly divided into 5 groups, each consisted of 8 rats: control group(CL), sham-operation group(SO), model group(ML), simvastatin intervention group(ST) and simvastatin plus L-NAME intervention(STN). The animals were sacrificed at 4 weeks after CME, A microscopy incorporated with an image analysis software (ImagePro-4) was employed to calculate the... |
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