The Study Of Cardioprotective Effects And Mechanisms Of Ischemic Postconditioning On Isolated Rat Heart Suffering From Ischemia And Reperfusion

PARTâ… THE CARDIOPROTECTIVE EFFECTS OF ISCHEMIC POSTCONDITIONING ON ISOLATED RAT HEART SUFFERING FROM ISCHEMIA AND REPERFUSIONObjective: To investigate the protective effects and mechanism of ischemic postconditioning on myocardial ischemia reperfusion injury.Methods: 32 Wistar rats were randomly divided into 4 groups: normal control group(NC), ischemia reperfusion group(IR), ischemic postcondi- tioning group(IPO), ischemic preconditioning group(IPC). Ischemia reper- fusion injury was induced by 40 min of global ischemia and 120min of reperfusion in isolated rat hearts. The cardiac functions, coronary flow(CF), cardiac troponin I(cTnI) content in coronary effluent,the activity of...