The New Routes Design And Synthesis Of Voglibose

Voglibose, a kind of α-Glucosidase inhibitors, is considered as a new generation of oral used anti-NIDDM agents. Based on the researches have been reported, we have designed a new approach to synthesis voglibose, which through the way of microbial transformation and chemical synthesis, and confirmed it with the method of ~1H-NMR, MS spectrum.Make use of the two intermediates: valienamine and validamine, through separation and transformation of validamycin broth, to obtain valiolamine, the key intermediate of voglibose by chemical modification, we introduced two difference ways to synthesis of the aim product, used valienamine and validamine, and their possibility for industrialization. The finding confirmed that the two ways were succeed.After that, we introduced a new approach to synthesis of valiolamine, by a series of reaction to the carbon-carbon double bond from the substrate of valienamine, including epoxidation, hydrogenolysis and so on, and obtained the aim product finally. The finding confirmed that the new way was succeed.The total yield of the new way is higher than the reported, also better...