Experimental Study On Role Of P38 Mitogen-Activated Protein Kinase On Cerebral Vasospasm After Subarachnoid Hemorrhage

cerebral vasospasm is a most commonly complication after aneurysmal subarachnoid hemorrhage, clinical evidence manifest that nearly 50% of patients will develop disability and 15 to 20% of patients will die. Cerebral vasospasm (CVS) following SAH is biphasic: early or temporary cerebral vasospasm and delayed or chronic cerebral vasospasm (DCV). Early cerebral vasospasm is induced by the mechanical stimulation in the cerebral vessels resulting from the subarachnoid blood. The DCV begins several days after the bleeding and that could be sustained for a longer period of time. DCV could be observed usually in the clinic but is difficult to treat it efficaciously. The vasodilator has no or little effect on the DCV. The patients with DCV will develop secondary infarction and the involved brain damage. The underlying pathogenic mechanisms remain obscure up to date. This fact has hindered the development of rational and specific treatments paradigms for CVS, especially for DCV. Some studies suggested that the lysate of the subarachnoid blood clot after SAH including hemoglobin(Hb), endothelin(ET), thrombin, and 5-hydroxytryptamine could induced the contraction of cerebral vessels. However it could not explain the p-...