Fluorescence Quantitative PCR Detection Of FLT3 Gene Expression In Acute Myeloid Leukemias And Its Clinical Implications

Backgroud:Acute leukemias are clonal malignant hematopoietic disorders that result from genetic alterations in normal hematopoietic stem cells. These alterations induce differentiation arrest and/or excessive proliferation of abnormal leukemic cells or blasts.Acute myeloid leukemia (AML) is heterogeneous. During the past several decades, improvements in chemotherapeutic regimens and supportive care have resulted in significant but modest progress in treating AML. Better understanding of the biology of AML has resulted in the identification of new therapeutic targets. Despite current optimism, most patients with AML still die of their disease. With better molecular definition and elucidation of the physiopathology of AML subtypes and development of new and targeted therapies, a better outcome for patients with AML may be achievable in the future.The prevalence and significance of several genetic abnormalities inpatients with acute myeloid leukemia have been reported. The most powerful prognostic factor in AML has been the karyotype of the leukemia cells. Three cytogenetic risk groups (favorable, intermediate, and poor) are widely accepted, but there is a practical...