Preliminary Study On The Expression Of ABC Transporters In Nasopharyngeal Carcinoma

Tumour is a disease which can severely endanger mankind's health, the Multi-Drug Resistance is always one of the key factors which limit the chemotherapy in tumor treatment. The possible drug-resistant mechanism includes pharmacological mechanism and cell mechanism. Among these it is highly concerned of the important role of ABC drug transporters played in the formation of the tumor multidrug resistance.ABC drug transporters also named ATP Binding Cassette Transporters is a special protein superfamily in the membrane transport protein families, these transporters can induce the transportation of many substrates through cell. It's found by recent research that the ABC drug transporters have pump function which is related to the decrease of medicament accumulation in the tumour cells, and it is the main reason that cause the tumor cells generate multidrug resistance (MDR), and this pump function also becomes the important defense mechanism which protect the tumour cells safe against the attack of chemo-treatment. While the discovery of tumor stem cell in many solid cancers has advanced our view in cancer chemotherapy. It is believed that in chemotherapy many cancer cells were killed but still leave tumor...