Studies On Freeze-Dried Liposomes Based Nasal Delivery System Of Vinpocetine

The objective of this study was to develop a good absorbed and stable preparation that can avoid the strong first-pass effect of vinpocetine (VIN).Considering its property and the request for therapy, liposome dispersion was prepared using the simple modified ethanol injection method. An orthogonal design was carried out to obtain the optimum component of liposome. In accelerated tests, it was found that the liposome suspension with good morphology and physical stability was produced.The dialysis method was developed to separate the free drug from VIN liposome, and the drug content, the entrapment efficiency of liposome before and after freeze-drying were determined by UV method.Screening from the various cryoprotectant, trehalose and mannitol were ensure to protect VIN liposome in freeze-drying. A good technique and formulation were confirmed to maintain the former structure and are of good stability.We used rat in situ nasal perfusion methods as an experimental model to investigate the regulation of nasal absorption. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption...