Evaluation Of The Efficacy Of Camellia Oil On Skin Permeation

For the purpose of evaluation of the efficacy of two different types of camellia oil (FCO, purified by activated charcoal filtration, and DCO, purified by distillation) on skin penetration in vitro and validation of quantitative microdialysis method in an excised porcine skin experimental system for determination of extracellular drug concentration in skin after topical application, the following experiments were carried out.The effect of FCO and DCO on the permeation of flurbiprofen (FP), used as a model drug, through rat skin was examined. FCO and DCO were applied to the skin as a pretreatment. Permeation of FP through the skin pretreated with FCO and DCO was significantly enhanced (p < 0.05) and the effects of FCO were greater than those of DCO. And the enhancement ratio of them was 3.52 and 2.11, respectively. The effect of camellia oil on FP permeation could be due to oleic acid, one of the major components of it. Further investigation was about the relationship between the enhancing effects and the partition coefficients of drugs between...