Studies On Paracetamol And Codeine Phosphate Sustained Release Pellets Capsule

Paracetamol and Codeine phosphate, which has been used for 40 years, is a kind of spirit medicine to treat the mild pain. In 1985, China produced the Paracetamol and Codeine phosphate No. 1, which contains 8.4mg codein phosphate and 500mg paracetamol. Its analgesia effect is proved in the clinic test. Then the Paracetamol and Codeine phosphate No. 2 which contains 15mg Codeine Phosphate and 300mg Paracetamol, and Paracetamol and Codeine phosphate No.3 have been produced. The new products have stronger analgesia effect and lower stomach and intestine reaction and hepatotoxicity by the paracetamol. It also has oral solution abroad now. The patient of chronic cancer must repeat using it to deal with the primary and middle age of pain. Now we want to produce its sustain-release preparation to enhance its clinic effect and decrease its toxic and side effect, also to reduce its taking times.The normal formulation with 15mg codeine phosphate and 150mg paracetamol is used to research the Paracetamol and Codeine phosphate sustain-release capsule. According to its metabolic character in body, prepare the paracetamol sustain release pellets to prolong its effective time and prepare the codeine phosphate fast release pellets to analgesia rapidly.This time also select the best prescription of the compound by orthogonal design on the base of their physical and chemical character research. The release rates study show the preparations release fit the equation of Higguchi. Meanwhile, I research the release rate testing method and the quality controlling method, and set up the accurately, convince, control easily quality research method. The stability of the preparation is also researched. The result demonstrates the good stability...