Chang Of Interleukin-4, Interleukin-12 In The Bronchoalveolar Lavage Fluid And The Serum Of The Patients With Idiopathic Pulmonary Fibrosis And Their Clinical Significance

PrefaceThe incidence rate of interstitial lung disease increases unceasingly, which has become an important kind of disease threatening human health. Idiopathic pulmonary fibrosis (IPF) is a kind of comparatively important interstitial lung disease, and its pathogenesis is not completely clear at present, but more and more researches show that cytokine especial inflammatory factor maybe act much importance to the occurrence and development of the disease. Interleukin( IL) is an important inflammatory monocytic factor acting to multiple target cells. IL -4 different to IL - 12 is belonged to another type of cytokine. It is thought highly that the proportional disequilibrium of Thl and Th2 cytokine which may cause the pulmonary fibrosis. The idea of this research is expected to realized more completely to the pathogenesis of IPF through discussing the action of IL - 4 and IL - 12 to the process of the disease and their clinical significance.Experimental MaterialInvestigated Objection; (1) IPF group ;30 patients with IPF, no other interstitial lung disease, through clinical examination, pulmonary function test, blood gas analysis, pulmonary high resolution computerized tomography (HRCT) , trans - branchioalveolar douche (BAL) and transbronchial lung biopsy (TBLB) . The diagnosis of these patients is in line with non - traumatic standard suggested by both American Thoracic Science (ATS) and Europe Respiration...