The Study Of Expression Of F-actin And RhoA In Experimental Hypoxia-ischemic WMD And The Protective Effect Of Forskolin On Cytoskeleton Of Neuro-cells

The first part: Establishment and evaluation of WMD model in premature ratsObjective:To establish the hypoxic-ischemic WMD model in premature rats and evaluate its feasibility.Methods:The 2 day-old SD rats were subjected to the ligation of right carotid artery(ischemia),and then they were put into a box full with 6% oxygen and 94% nitrogen for 4 hours(hypoxia).The light microscope was used to observe the brain pathological changes and the electron microscope was used to detect the brain ultrastructural changes after hypoxia and ischemia (HI) . Evaluate the rats at 1 month through psycho-behavior methods. T test was utilized to...