Study On The Mechanism Of Resistance In Klebsiella Pneumoniae To Fluoroquinolones

Klebsiella pneumoniae is a kind of usual opportunistic pathogen. For the past few years, its incidence of nosocomial infection is higher and higher, especially to children, aged people and those people who have low resistance. Quinolones as a kind of common drug, was used widely, even abuse to treat Klebsiella pneumoniae. At the same time, its resistance offered higher and higher tendency which make it difficult for treatment and even lead to therapeutic failure. In order to have effective treatment of Klebsiella pneumoniae infections in hospitals and develop new types of quinolones, it is important to study the antibacterial activity of quinolone-resistant Klebsiella pneumoniae in vitro and mechanisms of resistance which cause fluoroquinolone resistance.In order to study the antibacterial activity of quinolone-resistant Klebsiella pneumoniae in vitro, 14 strains were collected from 100 Klebsiella pneumoniae clinical isolates (MIC ≥ 4mg/L to ciprofloxacin). Minimum inhibitory comentrations(MICs) of antibiotic against Klebsiella pneumoniae were assayed by two-fold agar dilution...