Study Of The Levels Of Serum Transferrin Receptors(sTfR) And Iron Overload In Hemoglobin H Patients

Objective:To measure the levels of serum transferrin receptors ( sTfR ) in patients with hemoglobin H disease for investigation the iron metabolism ( sideropenic or iron overload ) and to guide the proper intervention. To get a better index of judging the iron overload in HbH patients by analysis of the values of sTfR and sTfR/lgSF.Methods :①Peripheral blood specimens were obtained from 50 cases of HbH patients and 30 cases of normal controls,the levels of sTfR and SF were examined by Enzyme Linked Immunosorbent Assays.②To judge the diagnosis efficiency of sTfR and sTfR/lgSF in HbH patient'iron metabolism by Receiver Operator Characteristic (ROC) curve analysis.Results :①The levels of sTfR in HbH patient group was 2.19—8.5 mg/L ,the mean value (6.74±1.02mg/L) was significantly lower than that in the control group(8.09±0.67 mg/L, P<0.01),except 7 patients;②the levels of SF in HbH patient group was 23.83—358.61μg/L , the mean value (203.19±84.77μg/L)was significantly higher than that in the control group(84.13±83.03μg/L, P<0.01), iron overload was found in 7 patients according to the diagnostic criteria[1];③The sTfR/lgSF value in HbH patient group(3.05±0.67) was significantly lower than that in control group(4.43±1.11, P<0.01);④No significantly difference was found between the sTfR value and SF value in children group(3-15 age) and adult group of HbH patients;...