The Clinical Research On The Relationship Between Rennin-Angiotensin-Aldosterone System And Ventricle Remodeling After Acute Myocardial Infarction Signs For Classification Of Syndrome Of TCM

[Objective] This Study is to investigate the relationship between the plasma rennin activity (PRA), the plasma concentration of angiotensin II (Ang II) ,aldosterone (Ald) in patients ventricle remodeling (VR) after acute myocardial infarction (AMI) and Zheng differentiation-classification of TCM(stagnation of phlegm-dampness, qi stagnation blood stasis, deficiency of YIN-blood, deficiency of YANG QI.TO study the essential and the Severity of pathogenetic condition of the classification of syndrome of TCM of the patients VR after AMI according the neurohormones,by which we can provide a all-around, reasonable, external, quantitative proof of the classification of syndrome of TCM of the patients VR after AMI.[ Method ] Measure the plasma concentration of angiotensin II (Ang II) , aldosterone (Ald) of the AMI patients after 7 days treatment by radioimmunological method. Meanwhile detect echocardiography to measure LVDd, LVESV , LVEDV, EF. Record patients gender, age, family history, et al to statistical analysis. Classify Zheng of TCM according to chest pain, breath hard, sweat, et al, by clinical experienced doctors.[Result] The LVDd, LVESV, LVEDV of the four groups all significantly increased compared with the normal, P<0.05. The LVDd, LVESV, LVEDV of the group of deficiency of YANG QI and qi stagnation blood stasis increased ,otherwise the EF decreased compared with stagnation of phlegm-dampness and deficiency of YIN-blood, P<0. 01. The PRA of deficiency of YANG QI Is significantly higher thanthat of stagnation of phlegm-dampness, qi stagnation blood stasis, deficiencyof YIN-blood, P<0. 01. The PRA of qi stagnation blood stasis significantly increased compared with stagnation of phlegm-dampness (P<0. 05) and deficiency of YIN-blood, (P<0. 01). And the PRA of stagnation of phlegm-dampness increase compared with deficiency of YIN-blood, (P<0. 05). The Agll of deficiency of YANG QI is the highest in this four group, significant difference compared with the other three groups,P<0.01. The Agll of stagnation of phlegm-dampness^ qi stagnation blood stasis^ deficiency of YANG QI all are significantly higher than that of deficiency of YIN-blood, P<0. 01. The ALD of qi stagnation blood stasis is higher than that of stagnation of phlegm-dampness and deficiency of YIN-blood, P<0.05.The ALD of deficiency of YIN-blood is significantly difference compared with with the other three groups, P<0. 01. That of stagnation of phlegm-dampness is increased compared with deficiency of YIN-blood, P<0. 01. [Conclusion] (l)The activation degree of RAS is different in the different group of ZHeng of TCM. The rule is deficiency of YANG QI> qi stagnation blood stasis>stagnation of phlegm-dampness>deficiency of YIN-blood. (2)There are negative correlation between the activation degree of RAS and the heart function in the patients of VR after AMI. (3)The PRA, Ang II and Aid can be a proof according which we can assess the patients VR after AMI...