Protective Effect And Mechanism Of Cortex Moutan On Experimental Autoimmune Hepatitis To C57BL/6 Mice

Autoimmune hepatitis is a chronic progressive inflammatory liver disease based on autoimmune reaction, enventually develop into liver fibrosis and liver cirrhosis. It is characterized histologically by a dense mononuclear cell infiltrate in the portal tract and serologically by the presence of non-organ and liver-specific autoantibodies, high transaminases and increased levels of IgG, in the absence of a known etiology. It usually responds to immunosuppressive treatment, which should be instituted as soon as diagnosis is made. But the mechanisms remain to be defined.Reserch has shown that cytokine and adhesion molecule such as nuclear factor kappa B (NF-κB ) , interelluar adhesion molecule-1 (ICAM-1) , tumor necrosis factor α ( TNF-α) and interleukin-6 ( IL-6) played important roles in occurrence and development of liver inflammation and liver fibrosis,but the reserch about the influence of NF-κB and its regulatory products to AIH was rare relatively..In recent years the research has discovered that C57BL/6 mice were immunized with syngeneic liver homogenate in complete Freund's adjuvant, so the experimental autoimmune...