Study On Expression Of Cyclin A And P21 In Endometriosis And Adenomyosis And Their Clinical Significance

Objective: Endometriosis is a common gynecological disease, causing pelvic pain, infertility, dysmenorrhea and other symptoms. Endometriosis occurs in 5%～10% of women in reproductive age and its morbidity has increased in recent years. The aetiology of endometriosis remains unclear. Thanks to its characters of local implantation and metastasis, endometriosis is considered to be a kind of"benign carcinoma", although it is actually a benign disease. Adenomyosis is a kind of disease with endometrium implanting in myometrium. Current researches have demonstrated that endometriosis share similar alterations with adenomyosis at immunological and genetic aspects, while results have uncovered that there is an intimate correlation between endometriosis and carcinoma in aetiology, histopathology and molecular genetics. Therefore, researchers have begun the studies on aetiology and mechanism of endometriosis from the angle of tumors'occurrence recently. During the process of tumor progression, nearly all the functions and effects of oncogenes and anti-oncogenes have been focused on the cell cycle regulations. So it might be speculated that the occurrence of endometriosis was associated with cells limitless...