Studies On Synthesis New NO-donor Drugs Containing Furoxanyl Moiety

Nitric oxide (NO), an important biological messenger and effector molecule, is involved in maintaining the physiological function in cardiovascular, immune and nervous systems. It has been reported to display a variety of activities, including control of vascular tone, platelet inhibition, cell adhesion, and immune regulation et al. Thus, nitric oxide plays an important role in the treatment of cardiovascular diseases such as hypertension and atherosclerosis.The furoxan (Furazan oxide, 1,2,5-oxadiazole-2-oxides) derivatives possessing wide-ranging biological activity. The results obtaind in the study of the furoxan derivatives as NO-donor were reported in the present paper. Recent results have shown that furoxan derivatives are able to activate the soluble guanylate cyclase by releasing nitric oxide under the action of thiol cofactors, so it can display a variety of biological activities such as vasodilation and the inhibition of platelet aggregation. Thus, the furoxan system can be useful in the design of NO-releasing drugs by incorporating with many drugs and active molecules.The lipophilic-hydrophilic balance of a compound is expressed by partition coefficient, which is critical for drug...