Measuring HO-1 In Cord Blood Of Full Term SGA And Its Expression In Cord Vessels

Objective: Small for gestational age (SGA), is born not only with low birth weight, growth retardation, high risk of asphyxia during delivery, intracranial hemorrhage, brain hypoxia injury, barrier in metabolism and congenital malformation, 10 times the perinatal mortality of appropriate for gestational age (AGA), but also with possibility of delayed development in physique, neuro-action and brainpower. Therefore research on disease cause, prophylaxis and treatment of SGA, decreasing perinatal mortality is of great significance. Heme Oxygenase (HO) is the speed-limit enzyme that generates carbon monoxide (CO), biliverdin and Fe in the course of heme metabolism. CO is a new kind of neurotransmission that is involved in adjustment of many kinds of physiological functions, inducement blood vessels relaxation and inhibition of platelet aggregation. Biliverdin can reduce to bilirubin. They are both anti-oxidant, protecting cell against oxidative damage. Investigations have already shown that HO can increase blood stream into uterus placenta, accelerate the formation of blood vessels, and protect placenta histiocyte. Enough blood stream into uterus placenta is the prerequisite for healthy growth of a fetus. Internal and external researches mainly focus on adults or...