The Experimental Study Of Chitosan Nanoparticles Mediate â…¢ Type NaPi Cotransportation Gene Transfection

Secondary hyperparathyroidism (SHPT) is a common and serious complication of chronic kidney disease (CKD). Phosphate retention, hypocalcemia, and calcitriol ( 1,25-dihydroxycholecalciferol ) deficiency contribute to the development of secondary hyperparathyroidism and CKD. The molecular pathogenesis of SHPT is not clear. Many studies have confirmed that PTH is one of the primary toxins in uremia patients and could not be eliminated by hemodialysis. PTH cumulation and persistent severe hyperparathyroidism result in the development of series of long-term complication, for instance, bone disease of kidney, myelofibrosis, intractable heart failure and arrhythmia, arterial vessel wall fibrosis,calcification and systolic/diastolic dysfunction, serious hypertension and hypotension; immune system disorder, infection and autonomic nerve disfunction ect. These complications will affect the quality of life and life span of patients. Since the morbidity and mortality of all the complications are high, understanding of the pathogenesis of SHPT and dealing with these patients has become a hot issue which allures many investigators interest.In 1937, Truman G Ddrake ect confirmed the hypothesis that hyperphosphatemia is one of the leading cause of Hyperproliferation of parathyroid cells using rabbit renal failure model. Other more recent research also showed that phosphorous concentration outside cells plays an important...