Studies Of Three Kinds Of The Herb Medicine Preparation Adjusts To Toxicity Of Cadmium Inside The Male Mice

There is the research enunciation, the Cadmium (Cd) have an obvious toxicity to procreative system in the male mammal. A little cadmium could cause testicle germ cell count decrease , epididymal sperm count cut down and vanish, and affect arrenotoky function. For inquirying in to Gypensldes, Astragalus Polysacharide and Glycyrrizin can control the toxicity of the Cadmium to procreative system , this experiments researches carried on the Cadmium to induce inner the bodies of testicle germ cell apoptosis. Research Methods: This experiment that total 110, the weight 18-22g and 25th age of male mice in Kunming were divided into random 11 groups which the control group, the Cd group and each density groups of low, medium and high of three kinds of the herb medicine. Male mice as object injected with several dose cadmium chloride after celiac injected Gypensldes ,Astragalus Polysacharide and Glycyrrizin. Testicle viscera coefficient was counted, testis was detected by pathological and the apoptosis of testis genital cell were assessed by employing TdT- mediated dUTP-biotin nick end labeling (TUNEL) technique.Research Results: To compare with the Cd group, the difference in every Chinese traditional medicine group was significant (P<0. 01). The Results showed that the apoptosis percent of genital cells in low, midst, high-dose groups of Gypensldes, Astragalus Polysacharide and Glycyrrizin are 18.01 + 1.7465; 15.02±4. 3901; 12. 47±1. 8139; 19.05±1.9589; 15. 32±4. 7612; 13. 60±3.8207; 27. 48 ±2. 5827; 22.15 ±2. 8593; 15. 51 ±4. 9810, whereas the control group and the Cd group are 10. 51±2. 3281, 36. 53±2. 2983. So the result indicate that Gypensldes, Astragalus Polysacharide and Glycyrrizin have protect effects on genital cell apoptosis in mice induced by Cadmium Chloride.Research Conclusion: 1)Gypensldes, Astragalus Polysacharide and Glycyrrizin have protect effects on genital cell apoptosis in mice induced by Cadmium Chloride. 2)The size of function is Gypensldes > Astragalus Polysacharide > Glycyrrizin.