Studies On The Relationship Between The Mutation Of HPV16 URR From Cervical Carcinoma Biopsies And The Occurrence Of Cervical Cancer In Xinjiang Uygur

Cervical cancer is the disease threatened women's life and health seriously, with the increase of its high suffering and death rate annually. High-risk HPVs (human papillomavirus, HPV) is closely linked to the development of cervical carcinomas. HPV16 and HPV18 are considered to be the major pathogenies, as the HPV16 and/or HPV18 found in tested cervical carcinomatous tissues is 80-90%. The data of cervical cancer epidemiology indicated that the incidence of HPV infection was high, there were variant strains of high-risk HPVs with altered cancer-causing potency. The incidence of cervical cancer was high among Uygur women living in southern Xinjiang and morbidity was 459~590/10,000. The suffering of cervical carcinoma was intimately associated with the infection of HPV16, as HPV16 finding rate in cervical carcinomatous tissues was 77.6- 82.6%. It is generally considered that the virulent oncoproteins E6/E7 plays critical roles in the formation course of HPV-induced cancer. The expression of HPV early gene was regulated by HPV URR, and the expression of HPV E6/E7 genes were regulated by many transcriptional factors via binding to URR. And mutations in HPV URR can alter its regulation function, thus impacting the expression of E6/E7 oncoproteins.In order to investigate the relationship between the mutations in HPV16 type upstream regulatory region(URR) of cervical cancerous biopsies from Uygur women and high incidence of cervical carcinoma among Uygur women in southern Xinjiang, total DNA was extracted from cervical cancerous biopsies. Using these DNA as...